Recurrent sepsis in secondary immunodeficiency induced by nasal steroid misuse
Sepse de repetição na imunodeficiência secundária por uso abusivo de corticoide nasal
Bruna Giavina-Bianchi; Adriana Pitchon; André Luiz Oliveira Feodrippe; Pedro Giavina-Bianchi
Abstract
Nasal corticosteroids are recommended as first-line therapy for patients with moderate-to-severe allergic rhinitis. We report a case of a patient who presented with recurrent sepsis and was found to have secondary immunodeficiency induced by inappropriate use of nasal corticosteroids, highlighting the risks associated with the misuse of this medication.
Keywords
Resumo
Recomenda-se o uso de corticoides nasais como tratamento de primeira linha na rinite alérgica moderada a grave. Relatamos o caso clínico de um paciente com sepse de repetição no contexto de imunodeficiência secundária ao uso inapropriado de corticoide nasal, destacando-se os riscos associados ao uso abusivo de tais medicamentos.
Palavras-chave
Referências
1. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-10.
2. Cain DW, Cidlowski JA. Immune regulation by glucocorticoids. Nat Rev Immunol. 2017;17(4):233-47.
3. Gurnell M, Heaney LG, Price D, Menzies-Gow A. Long-term corticosteroid use, adrenal insufficiency, and the need for steroid-sparing treatment in adult severe asthma. J Intern Med. 2021;290(2):240-56.
4. Giavina-Bianchi P, Aun MV, Takejima P, Kalil J, Agondi RC. United airway disease: current perspectives. J Asthma Allergy. 2016 May 11;9:93-100.
5. Fuchs M, Wetzig H, Kertscher F, Täschner R, Keller E. Iatrogenic Cushing syndrome and mutatio tarda caused by dexamethasone containing nose drops. HNO. 1999;47(7):647-50.
Submetido em:
07/11/2024
Aceito em:
14/11/2024
