Anaphylaxis associated with intracavernous penile
injection of prostaglandin E1 in combination with
papaverine and phentolamine

Mario Geller

doi:10.5935/2526-5393.20230030-en

Comunicação Clínica e Experimental

Anaphylaxis associated with intracavernous penile injection of prostaglandin E1 in combination with papaverine and phentolamine

Anafilaxia associada à injeção intracavernosa peniana de prostaglandina E1 em combinação com papaverina e fentolamina

Mario Geller

http://dx.doi.org/10.5935/2526-5393.20230030-en Arq Asma Alerg Imunol, vol.7, n2, p.222-224, 2023

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Abstract

Total radical prostatectomy for advanced prostate cancer may lead to sexual impotence, since it is associated with severe erectile dysfunction. A widely recommended treatment for this disabling condition is intracavernous penile injection of a mixture of prostaglandin E1, papaverine, and phentolamine. To our knowledge, we present the first case of anaphylaxis associated with intracavernous penile injection of prostaglandin E1 in combination with papaverine and phentolamine.

Keywords

Anaphylaxis, papaverine, phentolamine, prostaglandin E1, adverse effects, treatment with combination drugs.

Resumo

A prostatectomia radical total para câncer de próstata avançado pode levar à impotência sexual, associada a uma disfunção erétil grave. Um tratamento amplamente recomendado para esta condição incapacitante é a injeção intracavernosa no pênis de uma mistura de prostaglandina E1, papaverina e fentolamina. Até onde sabemos, estamos apresentando o primeiro caso de anafilaxia associada à injeção intracavernosa peniana de prostaglandina E1 em combinação com papaverina e fentolamina.

Palavras-chave

Anafilaxia, papaverina, fentolamina, prostaglandina E1, efeitos adversos, tratamento com medicamentos combinados.

Referências

1. Chandeck Montesa K, Chen Jiménez J, Tamayo JC, Rodríguez Antolín A, Alvarez González E. Prospective study of the effectiveness and side effects of intracavernous prostaglandin E1 versus papaverine or papaverine phentolamine in the diagnosis and treatment of erection dysfunction. Review of the literature. Actas Urol Esp. 1992;16(3):208-16.

2. Floth A, Schramek P. Intracavernous injection of prostaglandin E1 in combination with papaverine: enhanced effectiveness in comparison with papaverine plus phentolamine and prostaglandin E1 alone. J Urol. 1991;145(1):56-9.

3. Gushchin IS. Effect of prostaglandin E1 and papaverine on anaphylactic histamine liberation from mast cells. Patol Fiziol Eksp Ter. 1977;1:32-5.

4. Gushchin IS, Fredkhol'm B, Uvnas B. Effect of papaverine and prostaglandin E1 on preparation /48/80-induced histamine liberation from rat mast cells. Patol Fiziol Eksp Ter. 1975;6:3-7.

Submetido em:
20/10/2022

Aceito em:
28/11/2022